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Modulating fatty acid metabolism and composition of CHO cells by feeding high levels of fatty acids complexed using methyl-β-cyclodextrin

https://doi.org/10.1016/j.ymben.2025.04.005

Priem, Bradley; Cai, Xiangchen; Hong, Yu-Jun; Gilmore, Karl; Deng, Zijun; Chen, Sabrina; Naik, Harnish Mukesh; Betenbaugh, Michael J; Antoniewicz, Maciek R (September 2025, Metabolic Engineering)

Free, publicly-accessible full text available September 1, 2026
Ala-Cys-Cys-Ala dipeptide dimer alleviates problematic cysteine and cystine levels in media formulations and enhances CHO cell growth and metabolism

https://doi.org/10.1016/j.ymben.2024.07.008

Ladiwala, Pranay; Cai, Xiangchen; Naik, Harnish Mukesh; Aliyu, Lateef; Schilling, Martin; Antoniewicz, Maciek R; Betenbaugh, Michael J (September 2024, Metabolic Engineering)

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Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using 13C labeling experiments and kinetic modeling

https://doi.org/10.1016/j.ymben.2024.03.002

Naik, Harnish Mukesh; Cai, Xiangchen; Ladiwala, Pranay; Reddy, Jayanth Venkatarama; Betenbaugh, Michael J; Antoniewicz, Maciek R (May 2024, Metabolic Engineering)

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Self-assembly of a 5-fluorouracil and camptothecin dual drug dipeptide conjugate

https://doi.org/10.1039/d2ob00762b

Sun, Yuan; Fry, Cathleen M.; Shieh, Aileen; Cai, Xiangchen; Reardon, Thomas J.; Parquette, Jon R. (July 2022, Organic & Biomolecular Chemistry)

Nano-formulated, combinatory therapeutics that control the spatiotemporal aspects of drug release have potential to overcome many of the challenges faced in cancer therapy. Herein, we describe a peptide nanotube functionalized with two anticancer drugs, 5-fluoruracil (5-FU) and camptothecin (CPT). The nanotube was formed via peptide self-assembly, which positioned 5-FU on the surface at the aqueous interface; whereas, CPT was sequestered within the hydrophobic walls. Thus, two different release profiles were observed: rapid release of 5-FU, followed by slower, sustained production of CPT. This profile emerged from the rapid hydrolytic cleavage of 5-FU at the aqueous/nanotube interface, which produced a smaller nanotube comprised of the peptide fragment.
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